Mutational profile of pfdhfr, pfdhps, pfmdr1, pfcrt and pfk13 genes of P. falciparum associated with resistance to different antimalarial drugs in Osun state, southwestern Nigeria

Martín Ramírez, Alexandra; Akindele, Akeem Abiodun; González Mora, Vicenta; García, Luz; Lara, Nicole; de la Torre-Capitán Matías, Eva; Molina de la Fuente, Irene; Nassar, Sulaiman Adebayo; Ta-Tang, Thuy-Huong; Benito, Agustín; Berzosa, Pedro

doi:10.1186/s41182-025-00732-6

Table 2 Prevalence and percentage of combined pfdhfr and pfdhps haplotypes detected in P. falciparum isolates (N = 266)

From: Mutational profile of pfdhfr, pfdhps, pfmdr1, pfcrt and pfk13 genes of P. falciparum associated with resistance to different antimalarial drugs in Osun state, southwestern Nigeria

Combination of mutated codons	Haplotypes	Number (n)	Percentage (%)
51/59/108/437 (partially resistant) [25]	IRNI + ISGKAA	47	17.67
51/59/108/437/540 (fully resistant) [25]	IRNI + ISGEAA	0	0.00
51/59/108/437/540/581 (super resistant) [25]	IRNI + ISGEGA	0	0.00
51/59/108/436/437	IRNI + IAGKAA	30	11.28
51/59/108/436/437	IRNI + IFGKAA	32	12.03
51/59/108/431/436/437/540	IRNI + VAGEAA	1	0.38
51/59/108/437/613	IRNI + ISGKAs	2	0.75
51/59/108/437/581/613	IRNI + ISGKGS	7	2.63
51/59/108/437/581	IRNI + ISGKGA	21	7.89
51/59/108/431/436/437	IRNI + VAGKAA	6	2.26
51/59/108/431/436/437/581/613	IRNI + VAGKGS	26	9.77
51/59/108/431/436/437/581	IRNI + VAGKGA	12	4.51
51/59/108/431/437/613	IRNI + VSGKAS	1	0.38
51/59/108/431/437/581/613	IRNI + VSGKGS	1	0.38
51/59/108/431/437/581	IRNI + VSGKGA	3	1.13
51/59/108/436/581	IRNI + IAAKGA	3	1.13
51/59/108/436/581/613	IRNI + IAAKGS	1	0.38
51/59/108/436	IRNI + IAAKAA	3	1.13
51/59/108/436	IRNI + IFAKAA	1	0.38
108/436/437	NCNI + IFGKAA	1	0.38
59/108/436/437	NRNI + IFGKAA	1	0.38
51/59/108/436/613	IRNI + IAAKAS	1	0.38
51/59/108/436/437/613	IRNI + IAGKAS	16	6.02
51/59/108/436/437/581	IRNI + IAGKGA	15	5.64
51/59/108/436/437/581	IRNI + IFGKGA	11	4.14
51/59/108/436/437/581/613	IRNI + IAGKGS	11	4.14
59/108/436/437/581/613	NRNI + IAGKGS	1	0.38
51/108/437	ICNI + ISGKAA	2	0.75
437	NCSI + ISGKAA	1	0.38
51/59/108/431/436/581/613	IRNI + VFAKGS	1	0.38
51/59/108/436/437/613	IRNI + IFGKAS	1	0.38
51/59/108/436/437/581/613	IRNI + IFGKGS	1	0.38
51/59/108/431/436/437/613	IRNI + VAGKAS	3	1.13
51/108/431/436/437/581/613	ICNI + VAGKGS	1	0.38
59/108/431/436/437/581/613	NRNI + VAGKGS	1	0.38
51/59/108/431/581/613	IRNI + VSAKGS	1	0.38

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ISSN: 1349-4147

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